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KMID : 1134820160450030445
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 3 p.445 ~ p.451
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Enhancing Effect of Pteridium aquilinum and Aster scaber Added Doenjang on Immunomodulatory Activity
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Sung Nak-Yun
An Eun-Ju
Park Won-Jeong
Park Yoo-Young
Byun Eui-Hong
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Abstract
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This study demonstrated the immunological effects of methanol extracts from Doenjang added with wild plants (Pteridium aquilinum and Aster scaber) on bone-marrow derived macrophages and mouse splenocytes. Doenjang (DJ) and wild plant added Doenjang (WPDJ) extracts were treated to bone-marrow derived macrophages (BMDM) and splenocytes, and cell proliferation and cytokine production were measured. Cell proliferation of BMDM and splenocytes was more highly elevated in the WPDJ-treated group compared to the DJ-treated group. Cytokine [tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, IL-10, and IL-12] production in BMDM also significantly increased in the WPDJ-treated group. Similarly, in the case of cytokine production in splenocytes, WPDJ treatment highly increased production of Th 1 type cytokines [interferon (IFN)-γ and IL-2] but did not affect production of Th 2 type cytokines (IL-4). These results suggest that wild plants could improve the immunomodulatory activity of Doenjang and may be effective for the development Doenjang.
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KEYWORD
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wild plant, immune enhancing activity, bone-marrow derived macrophage, splenocyte, cytokine
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